To make the breadcrumb topping, combine panko breadcrumbs, 2 tablespoon melted butter, and ¼ cup parmesan cheese. Set aside.
Cook the elbow macaroni until al dente, in a large pot of salted water. When it's cooked drain the elbow pasta and run it under cold water until it's completely cool. Set aside.
To make the creamy cheese sauce, melt ⅓ cup butter in a medium pan, over medium heat. Add the flour and onion powder and stir until it's a smooth sauce. Cook for 2 min.
Whisk in the milk, cream, dry mustard powder, salt, and black pepper to taste. Cook over medium heat while stirring, until mixture thickens. Let mixture boil for 1-2 minutes while stirring.
Remove from heat and stir in cheddar cheese, gruyere swiss cheese and remaining ¼ parmesan cheese. Stir until cheese is melted and well blended.
Add in the cold cooked macaroni to the cheesy sauce and stir to fully combine. Pour into a greased 9 x 13 baking dish.
Top the macaroni and cheese with panko topping. Bake at 400 for 20-25 minutes, until bubbly and golden brown on top. Do not overbake. Cool 10 minutes before serving and enjoy.